Quality by Design in Enzyme Catalyzed Reactions
نویسندگان
چکیده
منابع مشابه
Enzyme-catalyzed phosphoryl transfer reactions.
PERSPECTIVES AND SUMMARY ................... ... ...................................................... 877 Classes of enzyme involving reactions at phosphorus...................................................... 878 COVALENT REACTION INTERMEDIATES, CRYPTIC AND OTHERWISE........................................................................................................ 879 Reactions of Pho...
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A fascinating group of enzymes has been shown to possess multiple active sites connected by intramolecular tunnels for the passage of reactive intermediates from the site of production to the site of utilization. In most of the examples studied to date, the binding of substrates at one active site enhances the formation of a reaction intermediate at an adjacent active site. The most common inte...
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Although the metabolic deamidation of several naturally occurring amides and their analogues, e.g. glutamine (l-4) and nicotinamide (5), has been extensively investigated, it appeared of interest to extend to simpler aliphatic and aromatic derivatives our knowledge of the variety of compounds undergoing enzyme-catalyzed deamidation. Therefore, three compounds, acetamide, butyramide, and benzami...
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Rieske nonheme iron oxygenases (ROs) are a well studied class of enzymes. Naphthalene 1,2-dioxygenase (NDO) is used as a model to study ROs. Previous work has shown how side-on binding of oxygen to the mononuclear iron provides this enzyme with the ability to catalyze stereospecific and regiospecific cis-dihydroxylation reactions. It has been well documented that ROs catalyze a variety of other...
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ژورنال
عنوان ژورنال: Organic & Medicinal Chemistry International Journal
سال: 2018
ISSN: 2474-7610
DOI: 10.19080/omcij.2018.06.555696